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Article

Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.

European journal of immunology - 1 May 1996

Johnston J M, Ihyer S R, Smith R S, Tai K F, Farmer T, Korsmeyer S J, Nadon N L, Carroll W L

Abstract excerpt

Somatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify cis-acting sequences that initiate and target hypermutation, we have made three minitransgenes containing different portions of an Ig heavy chain (IgH) locus. Each transgene is a passenger, bearing a nonsense...

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Identifiers

PMID: 8647167
DOI: 10.1002/eji.1830260515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.PMID 8647167Read ↗

Analysis of hypermutation in a mixed T-cell receptor beta/immunoglobulin heavy chain passenger transgene.Semantic proximity Read ↗

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Semantic proximity Read ↗

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.Semantic proximity Read ↗

Lack of somatic mutation in a kappa light chain transgene.Semantic proximity Read ↗

A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation.Semantic proximity Read ↗

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.Semantic proximity Read ↗

Somatic hypermutation of an immunoglobulin mu heavy chain transgene.Semantic proximity Read ↗

Somatic hypermutation in mouse lambda chains.Semantic proximity Read ↗

Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene.Semantic proximity Read ↗

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.Semantic proximity Read ↗

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene.Semantic proximity Read ↗

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