Article
Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.
European journal of immunology - 1 May 1996
Johnston J M, Ihyer S R, Smith R S, Tai K F, Farmer T, Korsmeyer S J, Nadon N L, Carroll W L
Abstract excerpt
Somatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify cis-acting sequences that initiate and target hypermutation, we have made three minitransgenes...
Topics
- Animals
- Base Sequence
- Crosses, Genetic
- Enhancer Elements, Genetic
- Gene Rearrangement, T-Lymphocyte
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Constant Regions
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Transgenes