Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.

doi:10.1006/jmbi.1999.3243

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Article

Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.

Journal of molecular biology - 26 Nov 1999

Ignatovich O, Tomlinson I M, Popov A V, Brüggemann M, Winter G

Abstract excerpt

The expressed human immunoglobulin Vlambda repertoire demonstrates a strong bias in the use of individual Vlambda segments. Mechanisms that underlie such biases can be divided into two categories: intrinsic genetic processes that lead to the preferential rearrangement and/or expression of certain segments; and selection following light chain expression. Here, we have used two approaches to investigate the factors...

Topics

Animals
B-Lymphocytes
CD3 Complex
Cloning, Molecular
DNA Primers
Gene Rearrangement
Genetic Variation
Humans
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Immunoglobulin lambda-Chains
Mice
Mice, Transgenic
Molecular Sequence Data
Nucleic Acid Amplification Techniques
Spleen

Source

Open in PubMed

Identifiers

PMID: 10610771
DOI: 10.1006/jmbi.1999.3243

Provenance

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