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Article

Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.

Journal of molecular biology - 26 Nov 1999

Ignatovich O, Tomlinson I M, Popov A V, Brüggemann M, Winter G

Abstract excerpt

The expressed human immunoglobulin Vlambda repertoire demonstrates a strong bias in the use of individual Vlambda segments. Mechanisms that underlie such biases can be divided into two categories: intrinsic genetic processes that lead to the preferential rearrangement and/or expression of certain segments; and selection following light chain expression. Here, we have used two approaches to investigate the factors...

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Source

Identifiers

PMID: 10610771
DOI: 10.1006/jmbi.1999.3243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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