Article
Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.
International immunology - 1 Apr 1994
Taylor L D, Carmack C E, Huszar D, Higgins K M, Mashayekh R, Sequar G, Schramm S R, Kuo C C, O'Donnell S L, Kay R M
Abstract excerpt
We have generated transgenic mice that contain human-sequence Ig miniloci and, because they are also homozygous for a targeted disruption of their endogenous heavy chain genes, must rely on the transgene sequences for B cell receptor expression. Although the human transgenes contain only a fraction of the intact human heavy chain locus, these defined sequences are able to at least partially restore the humoral...
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