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Article

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Jacobs H, Rajewsky K, Fukita Y, Bross L

Abstract excerpt

The generation of a diverse antigen receptor repertoire is fundamental for the functionality of the adaptive immune system. While the V(D)J recombination process that generates the primary antigen receptor repertoire is understood in great detail, it is still unclear by which mechanism immunoglobulin (Ig) genes are further diversified by somatic hypermutation. Using mouse strains that carry a non-functional,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11205324
DOI: 10.1098/rstb.2000.0756
PMCID: PMC1087699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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