Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing.

doi:10.1093/genetics/139.2.631

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Article

Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing.

Genetics - 1 Feb 1995

Bernstein M, Lersch R A, Subrahmanyan L, Cline T W

Abstract excerpt

Sex-lethal (Sxl) gene products induce female development in Drosophila melanogaster and suppress the transcriptional hyperactivation of X-linked genes responsible for male X-chromosome dosage compensation. Control of Sxl functioning by the dose of X-chromosomes normally ensures that the female-specific functions of this developmental switch gene are only expressed in diplo-X individuals. Although the immediate...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Mutational Analysis
DNA Transposable Elements
Dosage Compensation, Genetic
Drosophila Proteins
Drosophila melanogaster
Female
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Lethal

Genes, Switch

Insect Hormones

Male

Molecular Sequence Data

Mutation

RNA Precursors

Source

Open in PubMed Open full text

Identifiers

PMID: 7713421
DOI: 10.1093/genetics/139.2.631
PMCID: PMC1206370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7713421-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing.PMID 7713421Read ↗

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