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Article

Evolution of the Drosophila feminizing switch gene Sex-lethal.

Genetics - 1 Dec 2010

Cline Thomas W, Dorsett Maia, Sun Sha, Harrison Melissa M, Dines Jessica, Sefton Louise, Megna Lisa

Abstract excerpt

In Drosophila melanogaster, the gene Sex-lethal (Sxl) controls all aspects of female development. Since melanogaster males lacking Sxl appear wild type, Sxl would seem to be functionally female specific. Nevertheless, in insects as diverse as honeybees and houseflies, Sxl seems not to determine sex or to be functionally female specific. Here we describe three lines of work that address the questions of how, when,...

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Source

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Identifiers

PMID: 20837995
DOI: 10.1534/genetics.110.121202
PMCID: PMC2998314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolution of the Drosophila feminizing switch gene Sex-lethal.PMID 20837995Read ↗

Primary Sex Determination in Drosophila melanogaster Does Not Rely on the Male-Specific Lethal Complex.Semantic proximity Read ↗

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Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster.Semantic proximity Read ↗

An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal.Semantic proximity Read ↗

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The master switch gene sex-lethal promotes female development by negatively regulating the N-signaling pathway.Semantic proximity Read ↗

flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal.Semantic proximity Read ↗

Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethalSemantic proximity Read ↗

Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing.Semantic proximity Read ↗

The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA.Semantic proximity Read ↗

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