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Article

An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal.

Molecular and cellular biology - 1 Apr 1999

Yanowitz J L, Deshpande G, Calhoun G, Schedl P D

Abstract excerpt

In Drosophila melanogaster, Sex-lethal (Sxl) controls autoregulation and sexual differentiation by alternative splicing but regulates dosage compensation by translational repression. To elucidate how Sxl functions in splicing and translational regulation, we have ectopically expressed a full-length Sxl protein (Sx.FL) and a protein lacking the N-terminal 40 amino acids (Sx-N). The Sx.FL protein recapitulates the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10082569
DOI: 10.1128/MCB.19.4.3018
PMCID: PMC84096

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Source receipt: pubmed, retrieved 7 Sept 2026.

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