Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.

doi:10.1016/0092-8674(91)90157-t

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Article

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.

Cell - 19 Apr 1991

Bell L R, Horabin J I, Schedl P, Cline T W

Abstract excerpt

Sex-lethal is a binary switch gene that controls all aspects of Drosophila sexual dimorphism. It must be active in females and inactive in males. The on/off regulation reflects alternative RNA splicing in which full-length proteins are produced only in females. Here we investigate the role of Sxl in maintaining sexual pathway commitments. By ectopic expression of a female Sxl cDNA in transgenic male flies, we...

Topics

Alleles
Animals
Drosophila
Drosophila Proteins
Female
Gene Expression Regulation
Genes, Switch
Homeostasis
Insect Hormones
Male
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA Splicing

RNA-Binding Proteins

Restriction Mapping

Sex Determination Analysis

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2015624
DOI: 10.1016/0092-8674(91)90157-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2015624-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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