Article
Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination.
Development (Cambridge, England) - 1 Dec 1997
Hager J H, Cline T W
Abstract excerpt
With a focus on Sex-lethal (Sxl), the master regulator of Drosophila somatic sex determination, we compare the sex determination mechanism that operates in the germline with that in the soma. In both cell types, Sxl is functional in females (2X2A) and nonfunctional in males (1X2A). Somatic cell sex is determined initially by a dose effect of X:A numerator genes on Sxl transcription. Once initiated, the active...
Topics
- Animals
- Animals, Genetically Modified
- Crosses, Genetic
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Dosage
- Gene Expression Regulation, Developmental
- Germ Cells
- Insect Proteins
- Male
- Mutation
- Phenotype
- Polyploidy
- RNA Splicing
- RNA-Binding Proteins
- Ribonucleoprotein, U1 Small Nuclear