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Article

Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination.

Developmental biology - 15 Nov 2008

Lu Hong, Kozhina Elena, Mahadevaraju Sharvani, Yang Dun, Avila Frank W, Erickson James W

Abstract excerpt

In Drosophila, XX embryos are fated to develop as females, and XY embryos as males, because the diplo-X dose of four X-linked signal element genes, XSEs, activates the Sex-lethal establishment promoter, SxlPe, whereas the haplo-X XSE dose leaves SxlPe off. The threshold response of SxlPe to XSE concentrations depends in part on the bHLH repressor, Deadpan, present in equal amounts in XX and XY embryos. We...

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Identifiers

PMID: 18773886
DOI: 10.1016/j.ydbio.2008.08.012
PMCID: PMC2653429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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