flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal.

doi:10.1242/dev.126.23.5485

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Article

flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal.

Development (Cambridge, England) - 1 Dec 1999

Bhattacharya A, Sudha S, Chandra H S, Steward R

Abstract excerpt

The Sex-lethal (Sxl) gene is required in Drosophila females for sexual differentiation of the soma, for gem cell differentiation and dosage compensation. We have isolated three new alleles of female-lethal-on-X (flex), an X-linked female-lethal mutation and have characterized its function in sex determination. SXL protein is missing in flex/flex embryos, however transcription from both Sxl(Pe), the early Sxl...

Topics

Acetylation
Alleles
Animals
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Female
Fetal Death
Gene Dosage
Gene Expression Regulation, Developmental
Genes, Lethal
Germ Cells
Histones
Homozygote
Male

Source

Open in PubMed

Identifiers

PMID: 10556072
DOI: 10.1242/dev.126.23.5485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Mutation

Ovary

Promoter Regions, Genetic