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Article

Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.

Nucleic acids research - 11 Nov 1992

Sakamoto H, Inoue K, Higuchi I, Ono Y, Shimura Y

Abstract excerpt

Drosophila melanogaster somatic sexual differentiation is accomplished by serial function of the products of sex-determination genes. Sex-lethal (Sxl), is one such gene. It is functionally expressed only in female flies. The sex-specific expression of this gene is regulated by alternative mRNA splicing which results in either the inclusion or exclusion of the translation stop codon containing third exon. Although...

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Identifiers

PMID: 1454517
DOI: 10.1093/nar/20.21.5533
PMCID: PMC334383

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Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.PMID 1454517Read ↗

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.Semantic proximity Read ↗

Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.Semantic proximity Read ↗

An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal.Semantic proximity Read ↗

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.Semantic proximity Read ↗

Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination.Semantic proximity Read ↗

flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal.Semantic proximity Read ↗

The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA.Semantic proximity Read ↗

Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis.Semantic proximity Read ↗

Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing.Semantic proximity Read ↗

Evolution of the Drosophila feminizing switch gene Sex-lethal.Semantic proximity Read ↗

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.Semantic proximity Read ↗

The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.Semantic proximity Read ↗

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