Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.

doi:10.1093/nar/20.21.5533

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Article

Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.

Nucleic acids research - 11 Nov 1992

Sakamoto H, Inoue K, Higuchi I, Ono Y, Shimura Y

Abstract excerpt

Drosophila melanogaster somatic sexual differentiation is accomplished by serial function of the products of sex-determination genes. Sex-lethal (Sxl), is one such gene. It is functionally expressed only in female flies. The sex-specific expression of this gene is regulated by alternative mRNA splicing which results in either the inclusion or exclusion of the translation stop codon containing third exon. Although...

Topics

Animals
Base Sequence
Drosophila Proteins
Drosophila melanogaster
Exons
Female
Insect Hormones
Introns
Male
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Protein Binding

RNA Precursors

RNA Splicing

RNA-Binding Proteins

Uridine

Source

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Identifiers

PMID: 1454517
DOI: 10.1093/nar/20.21.5533
PMCID: PMC334383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1454517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.PMID 1454517Read ↗

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.Semantic proximity Read ↗

Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.Semantic proximity Read ↗

An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal.Semantic proximity Read ↗

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Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination.Semantic proximity Read ↗

flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal.Semantic proximity Read ↗

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Evolution of the Drosophila feminizing switch gene Sex-lethal.Semantic proximity Read ↗

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.Semantic proximity Read ↗

The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.Semantic proximity Read ↗

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