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Article

Differential effects of Sex-lethal mutations on dosage compensation early in Drosophila development.

Genetics - 1 Mar 1994

Bernstein M, Cline T W

Abstract excerpt

In response to the primary sex determination signal, X chromosome dose, the Sex-lethal gene controls all aspects of somatic sex determination and differentiation, including X chromosome dosage compensation. Two complementary classes of mutations have been identified that differentially affect Sxl somatic functions: (1) those impairing the "early" function used to set developmental pathway choice in response to...

Topics

Alleles
Animals
Chromosome Mapping
Dosage Compensation, Genetic
Drosophila
Female
Gene Expression
Genes, Insect
Genes, Lethal
Genes, Regulator
Genes, Switch
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Sex Determination Analysis

Sex Differentiation

X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 8005414
DOI: 10.1093/genetics/136.3.1051
PMCID: PMC1205862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8005414-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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