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Article

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Dyson E, Sucov H M, Kubalak S W, Schmid-Schönbein G W, DeLano F A, Evans R M, Ross J, Chien K R

Abstract excerpt

We have recently characterized a cardiac model of ventricular chamber defects in retinoid X receptor alpha (RXR alpha) homozygous mutant (-/-) gene-targeted mice. These mice display generalized edema, ventricular chamber hypoplasia, and muscular septal defects, and they die at embryonic day 15. To substantiate our hypothesis that the embryos are dying of cardiac pump failure, we have used digital bright-field and...

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Identifiers

PMID: 7638202
DOI: 10.1073/pnas.92.16.7386
PMCID: PMC41344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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