Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

doi:10.1073/pnas.92.16.7386

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Dyson E, Sucov H M, Kubalak S W, Schmid-Schönbein G W, DeLano F A, Evans R M, Ross J, Chien K R

Abstract excerpt

We have recently characterized a cardiac model of ventricular chamber defects in retinoid X receptor alpha (RXR alpha) homozygous mutant (-/-) gene-targeted mice. These mice display generalized edema, ventricular chamber hypoplasia, and muscular septal defects, and they die at embryonic day 15. T...

Topics

Animals
Disease Models, Animal
Female
Heart Atria
Heart Conduction System
Heart Defects, Congenital
Heart Ventricles
Homozygote
In Situ Hybridization
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Microscopy, Video

Myocardial Contraction

Phenotype

Pregnancy

RNA Probes

Receptors, Retinoic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7638202
DOI: 10.1073/pnas.92.16.7386
PMCID: PMC41344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7638202-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.PMID 7638202Read ↗

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.Semantic proximity Read ↗

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.Semantic proximity Read ↗

Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium.Semantic proximity Read ↗

Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish.Semantic proximity Read ↗

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.Semantic proximity Read ↗

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculatureSemantic proximity Read ↗

Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesisSemantic proximity Read ↗

Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formationSemantic proximity Read ↗

Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation.Semantic proximity Read ↗

Retinoid acid-induced effects on atrial and pacemaker cell differentiation and expression of cardiac ion channels.Semantic proximity Read ↗

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.Semantic proximity Read ↗

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.