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Article

Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formation

13 Dec 2005

Abstract excerpt

Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the systemic mutation of this receptor results in thinning of the myocardium and embryonic lethality. However, the molecular and cellular mechanisms controlled by RXRalpha signaling in this process are unclear, because a...

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PMID: 16352730
DOI: 10.1073/pnas.0504343102

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