Article
Retinoid acid-induced effects on atrial and pacemaker cell differentiation and expression of cardiac ion channels.
Differentiation; research in biological diversity - 1 Nov 2008
Gassanov Natig, Er Fikret, Zagidullin Naufal, Jankowski Marek, Gutkowska Jolanta, Hoppe Uta C
Abstract excerpt
Whereas retinoid acid (RA) signaling has been implicated in embryonic heart development, its significance in differentiation of specific cardiac subtypes remains largely unknown. In the present study, we took advantage of lineage-specific expression of atrial natriuretic peptide (ANP) in embryonic stem (ES) cells to study RA-induced effects on differentiation of atrial- and pacemaker-like phenotypes. Embryoid...
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