Article
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.
Development (Cambridge, England) - 1 May 1998
Chen J, Kubalak S W, Chien K R
Abstract excerpt
Mouse embryos lacking the retinoic acid receptor gene RXR(alpha) die in midgestation from hypoplastic development of the myocardium of the ventricular chambers and consequent cardiac failure. In this study, we address the issue of whether the RXRalpha gene is required in the cardiomyocyte lineage...
Topics
- Animals
- Cardiac Myosins
- Crosses, Genetic
- Gene Targeting
- Genes
- Genetic Vectors
- Heart Defects, Congenital
- Heart Ventricles
- Integrases
- Mice
- Mice, Mutant Strains
- Morphogenesis
- Myocardium
- Myosin Light Chains
- Phenotype
- Receptors, Retinoic Acid
- Recombination, Genetic
- Retinoid X Receptors