Article
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.
Genes & development - 1 May 1994
Sucov H M, Dyson E, Gumeringer C L, Price J, Chien K R, Evans R M
Abstract excerpt
We have established a targeted loss-of-function mutation in the RXR alpha gene in the mouse germ line that results in embryonic lethality between E13.5 and E16.5 when bred to homozygosity. The major defect responsible for lethality is hypoplastic development of the ventricular chambers of the heart, which is manifest as a grossly thinned ventricular wall with concurrent defects in ventricular septation. This...
Topics
- Animals
- Embryonic and Fetal Development
- Female
- Fetal Heart
- Gene Targeting
- Germ-Line Mutation
- Heart Ventricles
- Homozygote
- Liver
- Male
- Mice
- Mice, Inbred C57BL