Article
Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.
Development (Cambridge, England) - 1 Dec 1997
Kastner P, Messaddeq N, Mark M, Wendling O, Grondona J M, Ward S, Ghyselinck N, Chambon P
Abstract excerpt
Knock-out of the mouse RXRalpha gene was previously shown to result in a hypoplastic heart ventricular wall, histologically detectable in 12.5 dpc fetuses. We show here that a precocious differentiation can be detected as early as 8.5 dpc in ventricular cardiomyocytes of RXRalpha(-/-) mutants. This precocious differentiation, which is characterized by the presence of striated myofibrils, sarcoplasmic reticulum...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Female
- Heart Ventricles
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Phenotype
- Receptors, Retinoic Acid
- Retinoic Acid Receptor alpha
- Retinoid X Receptors
- Transcription Factors