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Article

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature

28 May 2018

Abstract excerpt

BACKGROUND: During the final stages of heart development the myocardium grows and becomes vascularized by means of paracrine factors and cell progenitors derived from the epicardium. There is evidence to suggest that retinoic acid (RA), a metabolite of vitamin A, plays an important role in epicardial-based developmental programming. However, the consequences of altered RA-signaling in coronary development have...

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PMID: 29806219
DOI: 10.1002/dvdy.24639

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