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Article

Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation.

Developmental biology - 15 Feb 1999

Kostetskii I, Jiang Y, Kostetskaia E, Yuan S, Evans T, Zile M

Abstract excerpt

Vitamin A is essential for normal embryonic cardiogenesis. The vitamin A-deficient phenotype in the avian embryo includes an abnormal heart tube closed at the sinus venosus and the absence of large vessels that normally connect the embryonic heart to the developing circulatory system. In vitamin A-deficient embryos the expression of cardiomyocyte differentiation genes, including atrial-specific myosin heavy...

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Identifiers

PMID: 9986733
DOI: 10.1006/dbio.1998.9139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation.PMID 9986733Read ↗

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Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development.Semantic proximity Read ↗

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.Semantic proximity Read ↗

Retinoic acid is a negative physiological regulator of N-cadherin during early avian heart morphogenesis.Semantic proximity Read ↗

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