Article
Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish.
Development (Cambridge, England) - 1 Dec 2003
Berdougo Eli, Coleman Hope, Lee Diana H, Stainier Didier Y R, Yelon Deborah
Abstract excerpt
The embryonic vertebrate heart is composed of two major chambers, a ventricle and an atrium, each of which has a characteristic size, shape and functional capacity that contributes to efficient circulation. Chamber-specific gene expression programs are likely to regulate key aspects of chamber formation. Here, we demonstrate that epigenetic factors also have a significant influence on chamber morphogenesis....
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