Article
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.
Cell - 23 Sept 1994
Kastner P, Grondona J M, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch J L, Dollé P, Chambon P
Abstract excerpt
A null mutation was generated in the mouse RXR alpha gene by targeted disruption. Growth deficiency occurred in heterozygote mice. Null mutants died in utero and displayed myocardial and ocular malformations. These malformations belong to the fetal vitamin A deficiency syndrome, supporting the id...
Topics
- Animals
- Aorta, Thoracic
- Cell Differentiation
- Cell Division
- Eye
- Eye Abnormalities
- Genes, Lethal
- Heart
- Heart Defects, Congenital
- Image Processing, Computer-Assisted
- Mice
- Mice, Knockout
- Morphogenesis
- Mutation
- Myocardium