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Article

Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

Biochimica et biophysica acta - 24 May 1995

Cortopassi G, Wang E

Abstract excerpt

Deleterious mitochondrial mutations accumulate during normal human aging in postmitotic tissues. How these mutations affect aging cells is currently unknown. This issue has been addressed in two ways. The first is to determine the likeliest effect of random mutations in the mitochondrial genome, and of the 4977 bp deletion and MELAS point mutation that rise in frequency with age. The results indicate that Complex...

Topics

Aging
Animals
Cell Death
DNA, Mitochondrial
Genome
Humans
MELAS Syndrome
Mice
Mice, Mutant Strains
Models, Biological
Mutation
NAD(P)H Dehydrogenase (Quinone)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Superoxides

Source

Identifiers

PMID: 7599205
DOI: 10.1016/0925-4439(95)00025-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7599205-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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