Article
Mitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria.
Mutation research - 1 Aug 1993
Kowald A, Kirkwood T B
Abstract excerpt
All eukaryotic cells rely on mitochondrial respiration as their major source of metabolic energy (ATP). However, the mitochondria are also the main cellular source of oxygen radicals and the mutation rate of mtDNA is much higher than for chromosomal DNA. Damage to mtDNA is of great importance because it will often impair cellular energy production. However, damaged mitochondria can still replicate because the...
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