Article
Mitochondria in organismal aging and degeneration.
Biochimica et biophysica acta - 9 Feb 1999
Cortopassi G A, Wong A
Abstract excerpt
Several lines of experimentation support the view that the genetic, biochemical and bioenergetic functions of somatic mitochondria deteriorate during normal aging. Deletion mutations of the mitochondrial genome accumulate exponentially with age in nerve and muscle tissue of humans and multiple other species. In muscle, a tissue that undergoes age-related fiber loss and atrophy in humans, there is an exponential...
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