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Article

The mitochondrial theory of aging: dead or alive?

Aging cell - 1 Feb 2003

Jacobs Howard T

Abstract excerpt

The mitochondrial theory of aging is based around the idea of a vicious cycle, in which somatic mutation of mtDNA engenders respiratory chain dysfunction, enhancing the production of DNA-damaging oxygen radicals. In turn, this is proposed to result in the accumulation of further mtDNA mutations. Finally, a bioenergetic crisis leads to overt tissue dysfunction and degeneration. A substantial body of circumstantial...

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PMID: 12882330
DOI: 10.1046/j.1474-9728.2003.00032.x

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