Article
Mitochondrial DNA mutations and apoptosis in mammalian aging.
Cancer research - 1 Aug 2006
Kujoth Gregory C, Leeuwenburgh Christiaan, Prolla Tomas A
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) accumulate during aging, but their significance to longevity and age-associated disease has been uncertain. Recently, in support of the hypothesis that mtDNA integrity is important, we have shown that age-associated diseases arise more rapidly in mice where mtDNA mutations and increased levels of apoptosis occur at higher rates than normal due to expression of an error-prone...
Topics
- Aging
- Animals
- Apoptosis
- DNA, Mitochondrial
- Humans
- Mice
- Mutation
- Neoplasms