Article
Mitochondrial mutations in mammalian aging: an over-hasty about-turn?
Rejuvenation research - 1 Jan 2004
de Grey Aubrey D N J
Abstract excerpt
The very low abundance of mitochondrial DNA (mtDNA) mutations in nearly all mammalian tissues even in old age has led most mitochondriologists to reject the idea that such mutations might have a causal role in aging, despite (1) the strong circumstantial (e. g., interspecies) evidence that they do have such a role, (2) the promulgation since 1998 of two detailed mechanisms whereby low levels of mtDNA mutations...
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