Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the electron transport gene SDHC on lifespan and cancer.

Experimental gerontology - 1 Oct 2006

Ishii Naoaki, Ishii Takamasa, Hartman Philip S

Abstract excerpt

Much attention has been focused on the hypothesis that oxidative damage contributes to cellular and organismal aging. A mev-1 mutation in the cytochrome b large subunit (SDHC) of complex II results in superoxide anion (O(2)(-)) overproduction and therefore leads to apoptosis and precocious aging in the nematode Caenorhabditis elegans. To extend these data, a transgenic mouse cell line was constructed with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochromes b

Share to Electron Transport Complex II

Share to Longevity

Share to Succinate Dehydrogenase

Share to Superoxides

Source

Identifiers

PMID: 16962276
DOI: 10.1016/j.exger.2006.06.037

Genes

SDHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the electron transport gene SDHC on lifespan and cancer.PMID 16962276Read ↗

Mitochondrial superoxide anion (O(2)(-)) inducible "mev-1" animal models for aging research.Semantic proximity Read ↗

Mitochondrial DNA repair and aging.Semantic proximity Read ↗

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging.Semantic proximity Read ↗

Model animals for the study of oxidative stress from complex II.Semantic proximity Read ↗

Effects of the mitochondrial respiratory chain on longevity in C. elegans.Semantic proximity Read ↗

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans.Semantic proximity Read ↗

Superoxide dismutase is dispensable for normal animal lifespan.Semantic proximity Read ↗

Mitochondrial theory of aging matures--roles of mtDNA mutation and oxidative stress in human aging.Semantic proximity Read ↗

Examining Sporadic Cancer Mutations Uncovers a Set of Genes Involved in Mitochondrial Maintenance.Semantic proximity Read ↗

Oxidative stress and aging in Caenorhabditis elegans.Semantic proximity Read ↗

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.