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Article

Deleterious role of superoxide dismutase in the mitochondrial intermembrane space.

The Journal of biological chemistry - 28 Mar 2008

Goldsteins Gundars, Keksa-Goldsteine Velta, Ahtoniemi Toni, Jaronen Merja, Arens Egils, Akerman Karl, Chan Pak H, Koistinaho Jari

Abstract excerpt

This work demonstrates how increased activity of copper-zinc superoxide dismutase (SOD1) paradoxically boosts production of toxic reactive oxygen species (ROS) in the intermembrane space (IMS) of mitochondria. Even though SOD1 is a cytosolic enzyme, a fraction of it is found in the IMS, where it is thought to provide protection against oxidative damage. We found that SOD1 controls cytochrome c-catalyzed...

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Identifiers

PMID: 18171673
DOI: 10.1074/jbc.M706111200

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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