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On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: a modelling study.

Aging cell - 1 Oct 2005

Kowald Axel, Jendrach Marina, Pohl Sandra, Bereiter-Hahn Jürgen, Hammerstein Peter

Abstract excerpt

The molecular mechanisms underlying the aging process are still unclear, but the clonal accumulation of mitochondrial deletion mutants is one of the prime candidates. An important question for the mitochondrial theory of aging is to discover how defective organelles might be selected at the expense of wild-type mitochondria. We propose that mitochondrial fission and fusion events are of critical importance for...

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PMID: 16164426
DOI: 10.1111/j.1474-9726.2005.00169.x

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