Article
Histochemical studies of progressive p53 mutations during colonic carcinogenesis in Sprague-Dawley rats induced by N-methyl-N-nitro-nitrosoguanidine or azoxymethane.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1994
Tendler Y, Reshef R, Cohen I, Barzilai M, Shasha S M, Rotter V, Shkolnik T
Abstract excerpt
We studied the increasing expression of the p53 tumor suppressor gene in Sprague-Dawley rats, chemically induced to develop colon cancer. p53 expression was evaluated histochemically at various stages of tumor progression (during a period of 40 weeks) that can be followed by colonic hyperprolifer...
Topics
- Adenocarcinoma
- Animals
- Azoxymethane
- Cell Nucleus
- Colonic Neoplasms
- Cytoplasm
- Epithelium
- Gene Expression
- Genes, p53
- Immunohistochemistry
- Male
- Methylnitronitrosoguanidine
- Mutation
- Rats
- Rats, Sprague-Dawley
- Tumor Suppressor Protein p53