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Article

Mutation and expression of the p53 gene during chemical hepatocarcinogenesis in F344 rats.

Biochimica et biophysica acta - 9 Jul 2003

Fu Yan, Deng Weiguo, Kawarada Yoshihiko, Kawagoe Masami, Ma Ying Zhe, Li Xinghua, Guo Naxin, Kameda Takashi, Terada Kunihiko, Sugiyama Toshihiro

Abstract excerpt

Inactivation of the p53 gene is one of the most frequent genetic alterations in carcinogenesis. We studied gene mutations, the mRNA expression of p53, and the accumulation of p53 protein in chemical hepatocarcinogenesis in rats. Samples consisting of 44 precancerous foci and 18 cancerous foci were collected by laser capture microdissection (LCM), and analyzed for mutations in rat p53 gene exons 5-8 by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Neoplasms

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Share to Polymorphism, Single-Stranded Conformational

Share to Rats, Inbred F344

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 12850271
DOI: 10.1016/s0167-4781(03)00113-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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