Article
Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.
The Journal of experimental medicine - 1 Jun 1998
Davidson W F, Giese T, Fredrickson T N
Abstract excerpt
B cell malignancies arise with increased frequency in aging individuals and in patients with genetic or acquired immunodeficiency (e.g., AIDS) or autoimmune diseases. The mechanisms of lymphomagenesis in these individuals are poorly understood. In this report we investigated the possibility that...
Topics
- Aging
- Animals
- B-Lymphocyte Subsets
- Fas Ligand Protein
- Leukemia Virus, Murine
- Leukemia, Lymphocytic, Chronic, B-Cell
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred MRL lpr
- Mice, SCID
- Phenotype
- Proviruses
- T-Lymphocyte Subsets
- Tumor Cells, Cultured
- Virus Integration
- fas Receptor