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Article

Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.

The Journal of experimental medicine - 1 Jun 1998

Davidson W F, Giese T, Fredrickson T N

Abstract excerpt

B cell malignancies arise with increased frequency in aging individuals and in patients with genetic or acquired immunodeficiency (e.g., AIDS) or autoimmune diseases. The mechanisms of lymphomagenesis in these individuals are poorly understood. In this report we investigated the possibility that mutations at the Fas (lpr) and Fasl (gld) loci, which prevent Fas-mediated apoptosis and cause an early onset benign...

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Identifiers

PMID: 9607923
DOI: 10.1084/jem.187.11.1825
PMCID: PMC2212316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.PMID 9607923Read ↗

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

Integrative analyses uncover mechanisms by which aging drives B cell lymphomaSemantic proximity Read ↗

Age-associated clonal B cells drive B cell lymphoma in mice.Semantic proximity Read ↗

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.Semantic proximity Read ↗

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