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Article

An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease.

Briefings in bioinformatics - 17 Jan 2022

Lin Cui-Xiang, Li Hong-Dong, Deng Chao, Liu Weisheng, Erhardt Shannon, Wu Fang-Xiang, Zhao Xing-Ming, Guan Yuanfang, Wang Jun, Wang Daifeng, Hu Bin, Wang Jianxin

Abstract excerpt

Alzheimer's disease (AD) has a strong genetic predisposition. However, its risk genes remain incompletely identified. We developed an Alzheimer's brain gene network-based approach to predict AD-associated genes by leveraging the functional pattern of known AD-associated genes. Our constructed network outperformed existing networks in predicting AD genes. We then systematically validated the predictions using...

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Identifiers

PMID: 34953465
DOI: 10.1093/bib/bbab522
PMCID: PMC8769916

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