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Article

Integrating polygenic and transcriptional risk scores for detecting Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Hwang Jiyun, Pyun Jung-Min, Lee Joo-Yeon, Park Jeong Su, Bice Paula J, Saykin Andrew J, Sung Joohon, Kim SangYun, Park Young Ho, Nho Kwangsik

Abstract excerpt

INTRODUCTION: Early detection of Alzheimer's disease (AD) is essential, yet existing biomarkers are invasive or costly. Polygenic risk scores (PRS) and transcriptional risk scores (TRS) may offer accessible alternatives, but their combined predictive performance remains understudied. METHODS: We calculated PRS and TRS using genome-wide genotype and blood transcriptome data from two ancestrally distinct cohorts:...

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Identifiers

PMID: 42080296
DOI: 10.1002/alz.71408
PMCID: PMC13137284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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