The de-UFMylating enzyme UFSP2 drives vascular smooth muscle cells phenotypic switching by sustaining the TCF21/ERK pro-survival pathway.

doi:10.1016/j.bbrc.2026.154399

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Article

The de-UFMylating enzyme UFSP2 drives vascular smooth muscle cells phenotypic switching by sustaining the TCF21/ERK pro-survival pathway.

Biochemical and biophysical research communications - 24 Sept 2026

Wang Jie, Liu Kaicheng, Li Wendi, Hu Jiajia, Zheng Jiaqi, Jia Mei, Qiu Wei, Su Ming

Abstract excerpt

BACKGROUND AND AIMS: To investigate the role of the de-UFMylating enzyme UFSP2, in regulating the phenotypic switching of vascular smooth muscle cells (VSMCs), a critical event in atherosclerosis. METHODS: UFSP2 expression was analyzed in injured mouse arteries (GEO: GSE40637) and human atherosclerotic renal arteries. In vitro studies utilized human aortic SMCs (HASMCs) where UFSP2 was either overexpressed or...

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