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Article

Berberine Inhibits Abdominal Aortic Aneurysm Formation and Vascular Smooth Muscle Cell Phenotypic Switching by Regulating the Nrf2 Pathway.

Journal of cellular and molecular medicine - 1 Apr 2025

Li Sanjun, Xiao Xiaoyong, Chang Yuechen, Xu Ziyao, Zheng Xianping, Zhou Haiwen, Ding Haiqiang, Lu Weiling, Li Tian, Tao Yu

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a life-threatening disease featuring extensive membrane destruction in the vascular wall, which is closely associated with the phenotypic switching of vascular smooth muscle cells (VSMC). A thorough understanding of the changes in regulatory factors during the pathogenesis of VSMC phenotypic switching is essential for medical treatments in AAA. NRF2 was deemed to hold a pivotal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40193135
DOI: 10.1111/jcmm.70509
PMCID: PMC11974455

Genes

USP15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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