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Article

RBM24 regulates phenotypic switching of smooth muscle cell in vascular remodeling by stabilizing JAK2 mRNA.

Cardiovascular research - 31 Dec 2025

Zhang Huawei, Liu Jing, Sun Daqian, Liu Yuxiu, Sun Wenhao, Wang Shanshan, Xu Xiuqin

Abstract excerpt

AIMS: Vascular remodeling plays a crucial role in the pathogenesis of vascular diseases. Our previous research highlighted the significance of RNA-binding protein 24 (RBM24) in the pathogenesis of dilated cardiomyopathy and the development of the zebrafish circulatory system. However, the specific role of RBM24 in vascular remodeling and its underlying mechanisms remain unclear. This study aims to elucidate the...

Topics

Animals
Vascular Remodeling
Humans
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
Kruppel-Like Factor 4
RNA-Binding Proteins
Signal Transduction
Phenotype
Janus Kinase 2
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Carotid Artery Injuries

RNA, Messenger

RNA Stability

Disease Models, Animal

Mice, Inbred C57BL

Mice, Knockout

Male

Source

Identifiers

PMID: 41216933
DOI: 10.1093/cvr/cvaf219

Genes

RBM24
JAK2
STAT3
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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