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Article

UFM1 suppresses VSMCs phenotypic switching and attenuates atherosclerosis by inhibiting AKT phosphorylation.

Biochemical pharmacology - 1 Aug 2026

Zhang Qianru, Aikebaier Mirenuer, Hu Yefan, Ma Xiaowen, Mao Ziming, Zhu Jing, Liu Yan, Chen Fengling

Abstract excerpt

Atherosclerosis is a chronic and progressive inflammatory disease that can lead to adverse cardiovascular and cerebrovascular events. Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a pivotal role in its development and progression, but the upstream regulatory mechanisms remain incompletely defined. Here, we identify ubiquitin-fold modifier 1 (UFM1), a ubiquitin-like protein, as a critical...

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Identifiers

PMID: 41974329
DOI: 10.1016/j.bcp.2026.117957

Genes

UFM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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