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Article

Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch.

JCI insight - 8 Oct 2021

Tierney J William, Evans Brian C, Cheung-Flynn Joyce, Wang Bo, Colazo Juan M, Polcz Monica E, Cook Rebecca S, Brophy Colleen M, Duvall Craig L

Abstract excerpt

Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migratory, and fibrotic. Previous studies suggest MAPK-activated protein kinase 2 (MK2) inhibition may limit VSMC proliferation and IH, although the molecular mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34622803
DOI: 10.1172/jci.insight.142339
PMCID: PMC8525639

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