Article
Sentrin-specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis.
Molecular biomedicine - 27 Nov 2025
Wang Zi, Wang Yinan, Yuan Ruosen, Ji Qingqi, Li Yanjie, Huo Huanhuan, Zhou Guo, Yan Xiangming, Shen Linghong, Cai Zhaohua, He Ben
Abstract excerpt
Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile toward a synthetic phenotype plays a critical role in atherosclerosis. Although the redox-sensitive sentrin/Small Ubiquitin-like Modifier (SUMO)-specific protease 3 (SENP3), which preferentially deconjugates SUMO2/3, has been linked to oxidative stress, its role in atherosclerosis remains poorly defined. In this study, we demonstrate...
Topics
- Kruppel-Like Factor 4
- Animals
- Kruppel-Like Transcription Factors
- Atherosclerosis
- Muscle, Smooth, Vascular
- Cysteine Endopeptidases
- Humans
- Mice
- Phenotype
- Myocytes, Smooth Muscle