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Article

APE1/Ref-1 redox function prevents VSMC phenotypic switching through KLF4 suppression.

Cellular signalling - 1 Jul 2026

Choi Yeon-Hee, Choi Eunju, Kim Sungmin, Jin Hao, Lee Eun-Ok, Lee Yu Ran, Joo Hee Kyoung, Kim Cuk-Seong, Jeon Byeong Hwa

Abstract excerpt

APE1/Ref-1, a multifunctional protein with redox activity, plays a pivotal role in maintaining cellular redox homeostasis and regulating gene expression. This study explored the role of APE1/Ref-1 deficiency on vascular smooth muscle cell (VSMC) phenotypic switching and its underlying mechanisms. Aorta with heterozygous APE1/Ref-1 deficiency (APE1/Ref-1+/-) exhibited increased oxidative stress and impaired...

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Share to 8-Hydroxy-2'-Deoxyguanosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

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Share to Kruppel-Like Factor 4

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Share to Muscle, Smooth, Vascular

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Source

Identifiers

PMID: 41791439
DOI: 10.1016/j.cellsig.2026.112470

Genes

KLF4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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