Article
circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF.
Cellular signalling - 1 Jul 2026
Zhao Lingdan, Li Yan, Bi Ran, Shen Jiayi, Gao Yingbo, Song Junhuai, Zhen Zekun, Zheng Bin, Lian Hongguang, Wen Jinkun, Zhang Xinhua
Abstract excerpt
Although circRNAs have been widely studied in various disease contexts, their roles in vascular smooth muscle cells (VSMCs) phenotypic modulation remain incompletely understood. This study aims to investigate the regulatory functions and molecular mechanisms of two newly identified circRNAs, circFAM53B-1 and circFAM53B-2, in VSMCs phenotypic switching. Here, we show that both circFAM53B-1 and circFAM53B-2 were...
Topics
- Serum Response Factor
- Muscle, Smooth, Vascular
- Animals
- Ubiquitins
- Kruppel-Like Factor 4
- Cytokines
- Phenotype
- Myocytes, Smooth Muscle
- RNA, Circular
- Humans
- Kruppel-Like Transcription Factors