Article
Distinct amyloid-β filament fold in individuals with APP Flemish mutation.
Nature structural & molecular biology - 1 Aug 2026
Khaki Peerzada Shariq Shaheen, Guillen-Poza Pablo Adrian, Wong Carlton, Kan Chloe, Sharma Rakesh, Sugimura Rio, Robinson Andrew C, Valbuena Alejandro, Ng Roy Chun-Laam, Yang Yang, Hervas Ruben
Abstract excerpt
The dominantly inherited Flemish mutation-an A692G substitution in the amyloid precursor protein, corresponding to an A21G change in amyloid-β (Aβ)-causes a rare, early-onset form of Alzheimer disease characterized by pronounced cerebral amyloid angiopathy and unusually large senile plaque cores. Here, we report cryo-electron microscopy structures of amyloid filaments extracted from the postmortem parietal lobes...
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