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Article

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric.

The American journal of pathology - 1 Aug 2002

Kumar-Singh Samir, Cras Patrick, Wang Rong, Kros John M, van Swieten Johan, Lübke Ursula, Ceuterick Chantal, Serneels Sally, Vennekens Krist'l, Timmermans Jean-Pierre, Van Marck Eric, Martin Jean-Jacques, van Duijn Cornelia M, Van Broeckhoven Christine

Abstract excerpt

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular Abeta deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of...

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Identifiers

PMID: 12163376
DOI: 10.1016/S0002-9440(10)64207-1
PMCID: PMC1850756

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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