Article
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta neuropathologica - 1 Mar 2023
Yang Yang, Zhang Wenjuan, Murzin Alexey G, Schweighauser Manuel, Huang Melissa, Lövestam Sofia, Peak-Chew Sew Y, Saito Takashi, Saido Takaomi C, Macdonald Jennifer, Lavenir Isabelle, Ghetti Bernardino, Graff Caroline, Kumar Amit, Nordberg Agneta, Goedert Michel, Scheres Sjors H W
Abstract excerpt
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer's disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case (AβPParc1) with the Arctic mutation. Most filaments consist of two pairs of non-identical protofilaments that comprise residues V12-V40...
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