Article

Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk of developing progressive dementia and early-onset Alzheimer’s disease (AD). This dementia is attributed to the increased gene dosage of the amyloid-β (Aβ) p...

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Literature Corpus work: d76665dd-5fdd-5eb2-82af-184d6e36b704
DOI: 10.1101/2024.04.02.587507

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