Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

1 Oct 2018

Abstract excerpt

The ordered assembly of tau protein into abnormal filaments is a defining characteristic of Alzheimer's disease (AD) and other neurodegenerative disorders. It is not known if the structures of tau filaments vary within, or between, the brains of individuals with AD. We used a combination of electron cryo-microscopy (cryo-EM) and immuno-gold negative-stain electron microscopy (immuno-EM) to determine the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30276465
DOI: 10.1007/s00401-018-1914-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common foldPMID 30276465Read ↗

Structures of filaments from Pick’s disease reveal a novel tau protein foldSemantic proximity Read ↗

Tau filaments in neurodegenerative diseasesSemantic proximity Read ↗

Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau 297–391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EMSemantic proximity Read ↗

Structure-based Classification of TauopathiesSemantic proximity Read ↗

Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tauSemantic proximity Read ↗

Tau and neurodegeneration.Semantic proximity Read ↗

Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile DementiaSemantic proximity Read ↗

Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathySemantic proximity Read ↗

Structure of Tau filaments in Prion protein amyloidoses.Semantic proximity Read ↗

Tau filaments with the Alzheimer fold in cases with <i>MAPT</i> mutations V337M and R406WSemantic proximity Read ↗

Cellular and pathological heterogeneity of primary tauopathies.Semantic proximity Read ↗

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.